In order to comply with the Pope's mandate, Fernando Calvetos asked Eugenio IV to transfer the bishopric from Rubicón to Gran Canaria in 1435. At the same time, the Catholic Monarchs evoked their desire for the construction of the Cathedral of Santa Ana. In 1487, the project to build a cathedral church on the island of Gran Canaria was proposed, and work began around 1497, but this first phase of construction lasted only until 1570, when it came to a standstill due to lack of funds.
It was not until 1776, with the arrival of the Tenerife architect and draughtsman, Diego Nicolás Eduardo, who took up the position of racionero in the Cathedral of Santa Ana, that the second phase of construction began in 1781, which still continues today. However, the very long history of the construction of the Cathedral means that different architectural styles overlap here, such as late Gothic, Neoclassical and Renaissance.