The history of the Panier district began almost 2,600 years ago, when the city of Marseille was founded under the name of Massalia. The Greeks chose this place to set down their luggage because of its elevated position and proximity to the sea. The agora, from which citizens could keep an eye on the activities of the port, was located on what is now the Place de Lenche, while the Butte des Moulins was home to the acropolis dedicated to Athena.
The district continued to develop as Marseille expanded. In the 12th century, the Confrérie du Saint-Esprit built a hospital, which later became the Hôtel Dieu and has now been transformed into a luxury hotel, the 5-star InterContinental Marseille. In the 18th century, a large hospice was built here: the Vieille Charité.